category_id	category_display_name	macrogroup_id	macrogroup_name	macrogroup_order	category_order_within_macrogroup	category_color	mean_NES	n_genesets_significant	n_pos_genesets	n_neg_genesets	n_genesets_mapped	n_genesets_evaluable	support_state	source_row_order	evidence_url	analysis_id	collection	tier	gsea_padj_cutoff	category_p_adjusted	minimum_enriched_sets	minimum_enriched_pct	n_sets_evaluable	n_sets_total	n_sets_missing_p	n_sets_not_eligible_or_absent	confidence_level	significant	status	support_schema_version	support_grade	support_label	minimum_support_pct_text	support_count	support_annotation	observed_NES_pattern	observed_NES_counts
DEVELOPMENT_MORPHOGENESIS	Development and morphogenesis	DEVELOPMENT_NEURAL	Developmental and neural programs	4	1	#E88BA1	0.152304208745147	236	131	105	1010	716	significant_member_sets	1	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=DEVELOPMENT_MORPHOGENESIS&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1.0143905644500296e-07	8	1.1173184357541899	716	1010	0	294	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	1.11%	8/716	S1 · ≥1.11% · 8/716	Observed NES of both signs	+411 / -305 / zero 0 / missing 0; N=716
NEUROGENESIS_SYNAPSE	Neurogenesis and synapse	DEVELOPMENT_NEURAL	Developmental and neural programs	4	2	#B9576E	-0.57528800956359305	144	43	101	791	579	significant_member_sets	2	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=NEUROGENESIS_SYNAPSE&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	0.0014968386285306508	1	0.17271157167530224	579	791	0	212	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	0.17%	1/579	S1 · ≥0.17% · 1/579	Observed NES of both signs	+266 / -313 / zero 0 / missing 0; N=579
DNA_DAMAGE_REPAIR_CHECKPOINTS	DNA damage, repair and checkpoints	GENOME_GENE_EXPRESSION	Genome and gene expression	7	1	#D99A66	-1.6152394115436901	146	5	141	295	236	significant_member_sets	3	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=DNA_DAMAGE_REPAIR_CHECKPOINTS&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1.0900657313105607e-19	17	7.2033898305084749	236	295	0	59	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	7.2%	17/236	S1 · ≥7.2% · 17/236	Observed NES of both signs	+26 / -210 / zero 0 / missing 0; N=236
RNA_PROCESSING_SPLICING_RNP	RNA processing and RNP biology	GENOME_GENE_EXPRESSION	Genome and gene expression	7	2	#D18649	-1.5356243415147	125	7	118	263	185	significant_member_sets	4	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=RNA_PROCESSING_SPLICING_RNP&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	2.1266625781917534e-30	12	6.4864864864864868	185	263	0	78	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	6.48%	12/185	S1 · ≥6.48% · 12/185	Observed NES of both signs	+24 / -161 / zero 0 / missing 0; N=185
TRANSCRIPTION_CHROMATIN_EPIGENETICS	Transcription, chromatin and epigenetics	GENOME_GENE_EXPRESSION	Genome and gene expression	7	3	#C17537	-0.81860026495709304	146	39	107	416	326	significant_member_sets	5	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=TRANSCRIPTION_CHROMATIN_EPIGENETICS&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1.9330023069973103e-15	7	2.147239263803681	326	416	0	90	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	2.14%	7/326	S1 · ≥2.14% · 7/326	Observed NES of both signs	+124 / -202 / zero 0 / missing 0; N=326
TRANSLATION_RIBOSOME	Translation and ribosome	GENOME_GENE_EXPRESSION	Genome and gene expression	7	4	#A96730	-1.8621949188995299	60	0	60	116	85	significant_member_sets	6	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=TRANSLATION_RIBOSOME&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1.0007705585419746e-21	13	15.294117647058824	85	116	0	31	0.94999999999999996	TRUE	significant	support-grades-v1	S2	Supported in at least one tenth	15.29%	13/85	S2 · ≥15.29% · 13/85	Observed NES of both signs	+10 / -75 / zero 0 / missing 0; N=85
IMMUNE_ADAPTIVE_ANTIGEN_MHC	Adaptive immunity and antigen presentation	IMMUNE_INFLAMMATION	Immune and inflammatory biology	8	1	#BDA838	2.12756382969825	238	237	1	328	254	significant_member_sets	7	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=IMMUNE_ADAPTIVE_ANTIGEN_MHC&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	2.9470610701944526e-70	104	40.944881889763778	254	328	0	74	0.94999999999999996	TRUE	significant	support-grades-v1	S3	Supported in at least one quarter	40.94%	104/254	S3 · ≥40.94% · 104/254	Observed NES of both signs	+246 / -8 / zero 0 / missing 0; N=254
IMMUNE_CYTOKINE_INFLAMMATORY	Cytokine and inflammatory signaling	IMMUNE_INFLAMMATION	Immune and inflammatory biology	8	2	#B09812	1.8481578004349299	376	372	4	535	428	significant_member_sets	8	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=IMMUNE_CYTOKINE_INFLAMMATORY&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	6.8768563417266329e-25	95	22.196261682242991	428	535	0	107	0.94999999999999996	TRUE	significant	support-grades-v1	S2	Supported in at least one tenth	22.19%	95/428	S2 · ≥22.19% · 95/428	Observed NES of both signs	+420 / -8 / zero 0 / missing 0; N=428
IMMUNE_CORE	Immune core	IMMUNE_INFLAMMATION	Immune and inflammatory biology	8	3	#9F8700	2.0053056409441901	117	115	2	185	134	significant_member_sets	9	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=IMMUNE_CORE&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	2.1125629923225436e-43	52	38.805970149253731	134	185	0	51	0.94999999999999996	TRUE	significant	support-grades-v1	S3	Supported in at least one quarter	38.8%	52/134	S3 · ≥38.8% · 52/134	Observed NES of both signs	+127 / -7 / zero 0 / missing 0; N=134
IMMUNE_INNATE_COMPLEMENT_PRR	Innate immunity, complement and PRR	IMMUNE_INFLAMMATION	Immune and inflammatory biology	8	4	#8B7600	1.8434065742960699	186	183	3	308	223	significant_member_sets	10	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=IMMUNE_INNATE_COMPLEMENT_PRR&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	5.9128097511471677e-19	38	17.04035874439462	223	308	0	85	0.94999999999999996	TRUE	significant	support-grades-v1	S2	Supported in at least one tenth	17.04%	38/223	S2 · ≥17.04% · 38/223	Observed NES of both signs	+217 / -6 / zero 0 / missing 0; N=223
METABOLISM_AA_ONECARBON	Amino acid and one-carbon metabolism	METABOLISM_BIOENERGETICS	Metabolism and bioenergetics	12	1	#8FB438	1.5769681959036199	92	87	5	251	156	significant_member_sets	11	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=METABOLISM_AA_ONECARBON&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	4.1574237841078337e-08	7	4.4871794871794872	156	251	0	95	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	4.48%	7/156	S1 · ≥4.48% · 7/156	Observed NES of both signs	+140 / -16 / zero 0 / missing 0; N=156
METABOLISM_CARBOHYDRATE_GLYCOLYSIS	Carbohydrate metabolism and glycolysis	METABOLISM_BIOENERGETICS	Metabolism and bioenergetics	12	2	#85AE28	1.36152045059564	39	37	2	172	112	significant_member_sets	12	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=METABOLISM_CARBOHYDRATE_GLYCOLYSIS&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	0.042834942702418936	1	0.8928571428571429	112	172	0	60	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	0.89%	1/112	S1 · ≥0.89% · 1/112	Observed NES of both signs	+86 / -26 / zero 0 / missing 0; N=112
DETOX_XENOBIOTIC_METABOLISM	Detoxification and xenobiotic metabolism	METABOLISM_BIOENERGETICS	Metabolism and bioenergetics	12	3	#7CA818	1.7569051085376299	64	64	0	126	87	significant_member_sets	13	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=DETOX_XENOBIOTIC_METABOLISM&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	0.00014281817184015714	7	8.0459770114942533	87	126	0	39	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	8.04%	7/87	S1 · ≥8.04% · 7/87	Observed NES of both signs	+81 / -6 / zero 0 / missing 0; N=87
METABOLISM_CORE	General metabolism	METABOLISM_BIOENERGETICS	Metabolism and bioenergetics	12	4	#73A208	0.95188996338489396	28	22	6	51	41	significant_member_sets	14	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=METABOLISM_CORE&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	2.1834347290517388e-16	4	9.7560975609756095	41	51	0	10	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	9.75%	4/41	S1 · ≥9.75% · 4/41	Observed NES of both signs	+29 / -12 / zero 0 / missing 0; N=41
METABOLISM_LIPID_FA	Lipid and fatty acid metabolism	METABOLISM_BIOENERGETICS	Metabolism and bioenergetics	12	5	#6C9A00	1.6415117379039801	253	244	9	637	460	significant_member_sets	15	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=METABOLISM_LIPID_FA&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1.650072204421804e-16	31	6.7391304347826084	460	637	0	177	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	6.73%	31/460	S1 · ≥6.73% · 31/460	Observed NES of both signs	+367 / -93 / zero 0 / missing 0; N=460
MITOCHONDRIA_OXPHOS_ETC	Mitochondria, OXPHOS and ETC	METABOLISM_BIOENERGETICS	Metabolism and bioenergetics	12	6	#669200	-1.6950180744366601	67	4	63	143	110	significant_member_sets	16	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=MITOCHONDRIA_OXPHOS_ETC&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1.1952682737019185e-11	16	14.545454545454545	110	143	0	33	0.94999999999999996	TRUE	significant	support-grades-v1	S2	Supported in at least one tenth	14.54%	16/110	S2 · ≥14.54% · 16/110	Observed NES of both signs	+19 / -91 / zero 0 / missing 0; N=110
METABOLISM_NUCLEOTIDE	Nucleotide metabolism	METABOLISM_BIOENERGETICS	Metabolism and bioenergetics	12	7	#608A00	0.0263037065236237	61	32	29	175	115	significant_member_sets	17	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=METABOLISM_NUCLEOTIDE&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	0.15135796646694358	0	0	115	175	0	60	0.94999999999999996	FALSE	not_significant	support-grades-v1		No minimum greater than zero could be supported	0%	0/115		Observed NES of both signs	+68 / -47 / zero 0 / missing 0; N=115
PEROXISOME_FAO	Peroxisome and fatty acid oxidation	METABOLISM_BIOENERGETICS	Metabolism and bioenergetics	12	8	#5B8200	2.0553258860061798	5	5	0	21	12	significant_member_sets	18	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=PEROXISOME_FAO&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	0.12151044841179942	0	0	12	21	0	9	0.94999999999999996	FALSE	not_significant	support-grades-v1		No minimum greater than zero could be supported	0%	0/12		Observed NES of both signs	+9 / -3 / zero 0 / missing 0; N=12
ECM_MATRIX_REMODELING	ECM and matrix remodeling	MICROENVIRONMENT_VASCULAR_ECM	Microenvironment, vascular and ECM	13	1	#38BD7E	1.4393534352173201	65	62	3	183	142	significant_member_sets	19	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=ECM_MATRIX_REMODELING&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	0.0002683258511581743	2	1.408450704225352	142	183	0	41	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	1.4%	2/142	S1 · ≥1.4% · 2/142	Observed NES of both signs	+117 / -25 / zero 0 / missing 0; N=142
VASCULAR_LYMPHATIC	Vascular, angiogenic and lymphatic biology	MICROENVIRONMENT_VASCULAR_ECM	Microenvironment, vascular and ECM	13	2	#008B4A	1.66914917606713	65	65	0	151	107	significant_member_sets	20	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=VASCULAR_LYMPHATIC&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	7.2593205548024705e-06	6	5.6074766355140184	107	151	0	44	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	5.6%	6/107	S1 · ≥5.6% · 6/107	Observed NES of both signs	+106 / -1 / zero 0 / missing 0; N=107
CELL_CYCLE_PROLIFERATION	Cell cycle and proliferation	PROLIFERATION_CELL_CYCLE	Proliferation and cell cycle	16	1	#00AD9A	-1.30094245003964	259	35	224	555	417	significant_member_sets	21	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=CELL_CYCLE_PROLIFERATION&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1.1625288421673781e-21	47	11.270983213429256	417	555	0	138	0.94999999999999996	TRUE	significant	support-grades-v1	S2	Supported in at least one tenth	11.27%	47/417	S2 · ≥11.27% · 47/417	Observed NES of both signs	+80 / -337 / zero 0 / missing 0; N=417
SIGNALING_CORE	Core cell signaling	SIGNALING_COMMUNICATION	Signaling and cell communication	20	1	#38BAD6	1.3777939891129101	219	202	17	714	555	significant_member_sets	22	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=SIGNALING_CORE&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1.438404934151987e-08	21	3.7837837837837838	555	714	0	159	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	3.78%	21/555	S1 · ≥3.78% · 21/555	Observed NES of both signs	+451 / -104 / zero 0 / missing 0; N=555
ENDOCRINE_HORMONAL	Endocrine and hormonal pathways	SIGNALING_COMMUNICATION	Signaling and cell communication	20	2	#1CB0D0	1.42212153269949	142	135	7	497	367	significant_member_sets	23	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=ENDOCRINE_HORMONAL&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	7.3657620587797871e-07	5	1.3623978201634876	367	497	0	130	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	1.36%	5/367	S1 · ≥1.36% · 5/367	Observed NES of both signs	+293 / -74 / zero 0 / missing 0; N=367
GROWTH_FACTOR_RTK	Growth factor and RTK pathways	SIGNALING_COMMUNICATION	Signaling and cell communication	20	3	#00A6CA	1.01717215536547	68	56	12	412	328	significant_member_sets	24	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=GROWTH_FACTOR_RTK&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	0.30508269740971522	0	0	328	412	0	84	0.94999999999999996	FALSE	not_significant	support-grades-v1		No minimum greater than zero could be supported	0%	0/328		Observed NES of both signs	+194 / -134 / zero 0 / missing 0; N=328
TGFB_SMAD	TGF-beta and SMAD signaling	SIGNALING_COMMUNICATION	Signaling and cell communication	20	4	#0097B8	1.2452204482992399	28	26	2	129	101	significant_member_sets	25	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=TGFB_SMAD&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1	0	0	101	129	0	28	0.94999999999999996	FALSE	not_significant	support-grades-v1		No minimum greater than zero could be supported	0%	0/101		Observed NES of both signs	+74 / -27 / zero 0 / missing 0; N=101
WNT_NOTCH_HEDGEHOG_HIPPO	Wnt, Notch, Hedgehog and Hippo	SIGNALING_COMMUNICATION	Signaling and cell communication	20	5	#0088A6	-0.60571683699624801	54	16	38	263	210	significant_member_sets	26	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=WNT_NOTCH_HEDGEHOG_HIPPO&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1	0	0	210	263	0	53	0.94999999999999996	FALSE	not_significant	support-grades-v1		No minimum greater than zero could be supported	0%	0/210		Observed NES of both signs	+82 / -128 / zero 0 / missing 0; N=210
APOPTOSIS_CELL_DEATH	Apoptosis and regulated cell death	STRESS_DEATH_PROTEOSTASIS	Stress, proteostasis and cell death	22	1	#7EA9EA	1.21436937309451	90	77	13	321	231	significant_member_sets	27	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=APOPTOSIS_CELL_DEATH&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1.2654608479565716e-07	2	0.86580086580086579	231	321	0	90	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	0.86%	2/231	S1 · ≥0.86% · 2/231	Observed NES of both signs	+160 / -71 / zero 0 / missing 0; N=231
AUTOPHAGY_LYSOSOME	Autophagy, lysosome and phagosome maturation	STRESS_DEATH_PROTEOSTASIS	Stress, proteostasis and cell death	22	2	#71A1E8	0.60683525846540598	26	17	9	154	110	significant_member_sets	28	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=AUTOPHAGY_LYSOSOME&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	7.689198458053076e-17	2	1.8181818181818181	110	154	0	44	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	1.81%	2/110	S1 · ≥1.81% · 2/110	Observed NES of both signs	+72 / -38 / zero 0 / missing 0; N=110
ER_STRESS_UPR	ER stress and unfolded protein response	STRESS_DEATH_PROTEOSTASIS	Stress, proteostasis and cell death	22	3	#6599E6	1.4390886776277101	3	3	0	48	36	significant_member_sets	29	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=ER_STRESS_UPR&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1	0	0	36	48	0	12	0.94999999999999996	FALSE	not_significant	support-grades-v1		No minimum greater than zero could be supported	0%	0/36		Observed NES of both signs	+23 / -13 / zero 0 / missing 0; N=36
HEAT_SHOCK_STRESS_RESPONSE	Heat shock and acute stress response	STRESS_DEATH_PROTEOSTASIS	Stress, proteostasis and cell death	22	4	#5991E4	-1.23182046521472	8	1	7	17	14	significant_member_sets	30	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=HEAT_SHOCK_STRESS_RESPONSE&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1	0	0	14	17	0	3	0.94999999999999996	FALSE	not_significant	support-grades-v1		No minimum greater than zero could be supported	0%	0/14		Observed NES of both signs	+4 / -10 / zero 0 / missing 0; N=14
HYPOXIA_HIF	Hypoxia and HIF programs	STRESS_DEATH_PROTEOSTASIS	Stress, proteostasis and cell death	22	5	#5388D6	1.5158510219577299	7	7	0	31	21	significant_member_sets	31	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=HYPOXIA_HIF&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1	0	0	21	31	0	10	0.94999999999999996	FALSE	not_significant	support-grades-v1		No minimum greater than zero could be supported	0%	0/21		Observed NES of both signs	+15 / -6 / zero 0 / missing 0; N=21
OXIDATIVE_STRESS_REDOX_ROS	Oxidative stress, redox and ROS	STRESS_DEATH_PROTEOSTASIS	Stress, proteostasis and cell death	22	6	#4E7FC8	1.2438922196018201	40	36	4	116	87	significant_member_sets	32	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=OXIDATIVE_STRESS_REDOX_ROS&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	0.04501580988333273	1	1.1494252873563218	87	116	0	29	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	1.14%	1/87	S1 · ≥1.14% · 1/87	Observed NES of both signs	+66 / -21 / zero 0 / missing 0; N=87
PROTEOSTASIS_UBIQUITIN_PROTEASOME	Proteostasis, ubiquitin and proteasome	STRESS_DEATH_PROTEOSTASIS	Stress, proteostasis and cell death	22	7	#4977BB	-1.17484824441539	72	8	64	214	162	significant_member_sets	33	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=PROTEOSTASIS_UBIQUITIN_PROTEASOME&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1	0	0	162	214	0	52	0.94999999999999996	FALSE	not_significant	support-grades-v1		No minimum greater than zero could be supported	0%	0/162		Observed NES of both signs	+40 / -122 / zero 0 / missing 0; N=162
ADHESION_JUNCTION_POLARITY	Adhesion, junctions and polarity	STRUCTURE_MOTILITY_PLASTICITY	Structure, motility and plasticity	24	1	#C693E7	1.0552006892477901	103	82	21	260	205	significant_member_sets	34	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=ADHESION_JUNCTION_POLARITY&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	2.1177674526913374e-35	15	7.3170731707317076	205	260	0	55	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	7.31%	15/205	S1 · ≥7.31% · 15/205	Observed NES of both signs	+144 / -61 / zero 0 / missing 0; N=205
CYTOSKELETON_CONTRACTILITY	Cytoskeleton and contractility	STRUCTURE_MOTILITY_PLASTICITY	Structure, motility and plasticity	24	2	#BB7FE2	0.0131841422094155	162	85	77	419	319	significant_member_sets	35	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=CYTOSKELETON_CONTRACTILITY&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	2.8340290310217947e-13	8	2.5078369905956115	319	419	0	100	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	2.5%	8/319	S1 · ≥2.5% · 8/319	Observed NES of both signs	+177 / -142 / zero 0 / missing 0; N=319
EMT_PLASTICITY	EMT and cell-state plasticity	STRUCTURE_MOTILITY_PLASTICITY	Structure, motility and plasticity	24	3	#AB6DD2	1.5120063970222299	4	4	0	34	21	significant_member_sets	36	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=EMT_PLASTICITY&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1	0	0	21	34	0	13	0.94999999999999996	FALSE	not_significant	support-grades-v1		No minimum greater than zero could be supported	0%	0/21		Observed NES of both signs	+13 / -8 / zero 0 / missing 0; N=21
MIGRATION_INVASION	Migration, invasion and motility programs	STRUCTURE_MOTILITY_PLASTICITY	Structure, motility and plasticity	24	4	#9560B8	1.62965874791882	92	86	6	215	150	significant_member_sets	37	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=MIGRATION_INVASION&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	1.9869491788234818e-18	21	14	150	215	0	65	0.94999999999999996	TRUE	significant	support-grades-v1	S2	Supported in at least one tenth	14%	21/150	S2 · ≥14% · 21/150	Observed NES of both signs	+122 / -28 / zero 0 / missing 0; N=150
ION_TRANSPORT_HOMEOSTASIS	Ion transport and homeostasis	TRANSPORT_TRAFFICKING_HOMEOSTASIS	Transport, trafficking and homeostasis	25	1	#E486CC	1.2251471874400399	83	73	10	382	272	significant_member_sets	38	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=ION_TRANSPORT_HOMEOSTASIS&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	4.6805371929954743e-06	6	2.2058823529411766	272	382	0	110	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	2.2%	6/272	S1 · ≥2.2% · 6/272	Observed NES of both signs	+196 / -76 / zero 0 / missing 0; N=272
TRANSPORT_LOCALIZATION	Transport and localization	TRANSPORT_TRAFFICKING_HOMEOSTASIS	Transport, trafficking and homeostasis	25	2	#DD64BE	0.249064917127231	139	82	57	418	293	significant_member_sets	39	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=TRANSPORT_LOCALIZATION&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	6.9500711492278733e-08	7	2.3890784982935154	293	418	0	125	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	2.38%	7/293	S1 · ≥2.38% · 7/293	Observed NES of both signs	+163 / -130 / zero 0 / missing 0; N=293
VESICLE_SECRETORY_TRAFFICKING	Vesicle, endocytosis, exocytosis and secretion	TRANSPORT_TRAFFICKING_HOMEOSTASIS	Transport, trafficking and homeostasis	25	3	#B5529C	-0.014222869324192601	87	43	44	373	282	significant_member_sets	40	../../../evidence/responders_vs_pd_on/GOBP-C2/index.html?category=VESICLE_SECRETORY_TRAFFICKING&analysis_id=responders_vs_pd_on&collection=GOBP-C2&tier=core	responders_vs_pd_on	GOBP-C2	core	0.25	2.4098088085994045e-07	6	2.1276595744680851	282	373	0	91	0.94999999999999996	TRUE	significant	support-grades-v1	S1	Enrichment supported; minimum below 10%	2.12%	6/282	S1 · ≥2.12% · 6/282	Observed NES of both signs	+130 / -152 / zero 0 / missing 0; N=282